Our new study suggests that astrocytes can form an "immune memory" that, in non-disease conditions, helps microglia clear amyloid-beta. We demonstrated this phenomenon in co-cultures of hiPSC-derived astrocytes and microglia, AD cerebral organoids, and in vivo mouse models. This protective mechanism is impaired by APOE4.
Please check our work published in Nature Communications.
https://www.nature.com/articles/s41467-025-62995-1
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