• Meyer K*, Feldman HM*, Lu T, Drake D, Lim ET, Ling KH, Bishop NA, Pan Y, Seo J, Lin YT, Su SC, Church GM, Tsai LH, Yankner BA (2019) REST and neural gene network dysregulation in iPSC models of Alzheimer’s disease. Cell Rep 26(5):1112-1127


  • Jung YJ*, Kim YH*, Bhalla M, Lee SB#, Seo J# (2018) Genomics: New light on Alzheimer’s disease research. Int. J. Mol. Sci 19(12):3771
  • Lin YT*, Seo J*, Gao F, Feldman HM, Wen HL, Penney J, Cam HP, Gjoneska E, Raja WK, Cheng J, Rueda R, Kritskiy O, Abdurrob F, Peng Z, Milo B, Yu CJ, Elmsaouri S, Dey D, Ko T, Yankner BA, Tsai LH (2018) APOE4 causes widespread molecular and cellular alterations associated with Alzheimer’s disease phenotypes across human iPSC-derived brain cell types. Neuron 98(6):1141-1154. (Selected for F1000 prime :
  • Godin S, Seo J, Tsai LH. ‘Neurodegenerative diseases and the aging brain’ in The molecular and cellular basis of neurodegenerative diseases (2018) Wolfe M. ed. ELSEVIER (Book Chapter)


  • Seo J*, Kritskiy O*, Watson LA, Barker SJ, Dey D, Raja WK, Lin YT, Ko T, Cho S, Penney J, Silva MC, Sheridan SD, Lucente D, Gusella JF, Dickerson BC, Haggarty SJ, Tsai LH (2017) Inhibition of p25/Cdk5 attenuates tauopathy in mouse and iPSC models of frontotemporal dementia. J Neurosci 37(41):9917-9924.
  • Penney J, Seo J, Kritskiy O, Elmsaouri S, Gao F, Pao PC, Su SC, Tsai LH (2017) Loss of protein arginine methyltransferase 8 alters synapse composition and function, resulting in behavioral defects. J Neurosci 37(36):8655-8666.
  • Shukla V, Seo J, Binukumar BK, Amin ND, Reddy P, Grant P, Kuntz S, Kesavapany S, Steiner J, Mishra SK, Tsai LH, Pant HC. (2017) TFP5, a peptide inhibitor of aberrant and hyperactive Cdk5/p25 attenuates pathological phenotypes and restores synaptic function in CK-p25Tg mice. J Alzheimers Dis 56(1):335-349.


  • Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH. (2016) Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature 540 (7632):230-235.
  • (Selected for F1000 prime :
  • Raja WK, Mungenast AE, Lin YT, Ko T, Abdurrob F, Seo J, Tsai LH. (2016) Self-organizing 3D human neural tissue derived from induced pluripotent stem cells recapitulate Alzheimer’s disease phenotypes. PLoS One 11(9):e0161969 (Selected for F1000 prime :


  • Madabhushi R, Gao F, Pfenning AR, Pan L, Yamakawa S, Seo J, Rueda R, Phan TX, Yamakawa H, Pao PC, Stott RT, Gjoneska E, Nott A, Cho S, Kellis M, Tsai LH. (2015) Activity-induced DNA breaks govern the expression of neuronal early-response genes. Cell 161(7):1592-605. (Selected for F1000 prime :
  • Siegert S, Seo J*, Kwon EJ*, Rudenko A*, Cho S, Wang W, Flood Z, Martorell AJ, Ericsson M, Mungenast AE, Tsai LH. (2015) The schizophrenia risk gene product miR-137 alters presynaptic plasticity. Nat Neurosci 18(7):1008-16. (Selected for F1000 prime :
  • Rei D, Mason X*, Seo J*, Gräff J, Rudenko A, Wang J, Rueda R, Siegert S, Cho S, Canter RG, Mungenast AE, Deisseroth K, Tsai LH. (2015) Basolateral amygdala bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway. Proc Natl Acad Sci U S A 112(23):7291-6.
  • Rudenko A*, Seo J*, Hu J, Su SC, de Anda FC, Durak O, Ericsson M, Carlen M, Tsai LH. (2015) Loss of cyclin-dependent kinase 5 from parvalbumin interneurons leads to hyperinhibition, decreased anxiety, and memory impairment. J Neurosci 35(6):2372-83.
  • Park H*, Han KS*, Seo J*, Lee J*, Dravid SM, Woo J, Chun H, Cho S, Bae JY, An H, Koh W, Yoon BE, Berlinguer-Palmini R, Mannaioni G, Traynelis SF, Bae YC, Choi SY, Lee CJ. (2015) Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors. Mol Brain 8(1):7.
  • Nott A, Cho S, Seo J, Tsai LH. (2015) HDAC2 expression in parvalbumin interneurons regulates synaptic plasticity in the mouse visual cortex. Neuroepigenetics 1:34-40.


  • Seo J, Tsai LH. (2014) Neuronal differentiation: 5-HT6R can do it alone. Nat Chem Biol 10(7):488-9.
  • Seo J, Giusti-Rodriguez P, Zhou Y, Rudenko A, Cho S, Ota KT, Park C, Patzke H, Madbhushi R, Pan L, Mungenast AE, Guan JS, Delalle I, Tsai LH. (2014) Activity-dependent p25 generation regulates synaptic plasticity and Aβ-induced cognitive impairment. Cell 157(2):486-98.
  • Gräff J, Joseph NF, Horn ME, Samiei A, Meng J, Seo J, Rei D, Bero AW, Phan TX, Wagner F, Holson E, Xu J, Sun J, Neve RL, Mach RH, Haggarty SJ, Tsai LH. (2014) Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories. Cell 156(1-2):261-76.


  • Rudenko A, Dawlaty MM, Seo J, Cheng AW, Meng J, Le T, Faull KF, Jaenisch R, Tsai LH. (2013) Tet1 is critical for neuronal activity-regulated gene expression and memory extinction. Neuron 79(6);1109-22.


  • Seo J*, Hong J*, Lee SJ, Choi SY. (2012) c-Jun N-terminal phosphorylation is essential for hippocampal synaptic plasticity. Neurosci Lett 531(1):14-9.
  • Su SC, Seo J, Pan JQ, Samuels BA, Rudenko A, Ericsson M, Neve RL, Yue DT, Tsai LH. (2012) Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5. Neuron 75(4):675-87.
  • Kang JA, Lee K, Lee KM, Cho S, Seo J, Hur EM, Park CS, Baik JH, Choi SY. (2012) Desipramine inhibits histamine H1 receptor-induced Ca2+ signaling in rat hypothalamic cells. PLoS One 7(4):e36185
  • Gräff J, Rei D, Guan JS, Wang WY, Seo J, Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M, Su SC, Samiei A, Joseph N, Haggarty SJ, Delalle I, Tsai LH. (2012) An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature 483(7388):222-6.
  • Seo J, Kim K, Jang S, Han S, Choi SY, Kim E. (2012) Regulation of hippocampal LTP and LTD by diacylglycerol kinase zeta. Hippocampus 22(5):1018-26.


  • Won H, Mah W, Kim E, Kim JW, Hahm EK, Kim MH, Cho S, Kim J, Jang H, Cho SC, Kim BN, Shin MS, Seo J, Jeong J, Choi SY, Kim D, Kang C, Kim E. (2011) GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice. Nat Med 17(5):566-72. (Selected for F1000 prime :
  • Yang J*, Seo J*, Nair R, Han S, Jang S, Kim K, Han K, Paik SK, Choi J, Lee S, Bae YC, Topham MK, Prescott SM, Rhee JS, Choi SY, Kim E. (2011) DGKi regulates presynaptic release, excitatory transmission, and presynaptic mGluR-LTD. EMBO J 30(1): 165-80.


  • Hong J, Cho IH, Suh EC, Kwak KI, Seo J, Choi SY Park HW, Jo EK, Lee S, Lee K, Lee SJ. (2010) Microglial Toll-like receptor 2 contributes to kainic acid-induced glial activation and hippocampal neuronal cell death. J Biol Chem 285(50): 39447-57.
  • Oh D*, Han S*, Seo J*, Lee JR*, Cho J, Groffen J, Kim K, Cho YS, Choi HS, Shin H, Woo J, Won H, Park SK, Kim SY, Jo J, Whitcomb DJ, Cho K, Kim H, Bae YC, Heisterkamp N, Choi SY, Kim E. (2010) Regulation of Synaptic Rac1 Activity, LTP maintenance, and Learning and Memory by BCR and ABR Rac GTPase- activating proteins. J Neurosci 30(42): 14134-44.
  • Seo J*, Koo NY*, Choi W Y, Kang JA, Min JH, Jo SH, Lee SJ, Oh SB, Kim JS, Lee JH, Choi SY, Park K. (2010) Sphingosine-1-phosphate Signaling in Human Submandibular Cells. J Dent Res. 89(10): 1148-53.


  • Han K*, Kim MH*, Seeburg D, Seo J, Verpelli C, Han S, Chung HS, Ko J, Lee HW, Kim K, Heo WD, Meyer T, Kim H, Sala C, Choi SY, Sheng M, Kim E. (2009) Regulated RalBP1 binding to RalA and PSD-95 controls AMPA receptor endocytosis and LTD. PLoS Biol. 7(9):e1000187. (Selected for F1000 prime :
  • Kim K, Yang J, Zhong XP, Kim MH, Kim YS, Lee HW, Han S, Choi J, Han K, Seo J, Prescott SM, Topham MK, Bae YC, Koretzky G, Choi SY, Kim E. (2009) Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance. EMBO J. 28(8):1170-9.
  • Kim MH*, Choi J*, Yang J*, Chung W*, Kim JH, Paik SK, Kim K, Han S, Won H, Bae YS, Cho SH, Seo J, Bae YC, Choi SY, Kim E. (2009) Enhanced NMDA receptor-mediated synaptic transmission, enhanced long-term potentiation, and impaired learning and memory in mice lacking IRSp53. J Neurosci. 29(5):1586-95.


  • Hayashi ML, Rao BS, Seo J, Choi HS, Dolan BM, Choi SY, Chattarji S, Tonegawa S. (2007) Inhibition of p21- activated kinase rescues symptoms of fragile X syndrome in mice. Proc Natl Acad Sci U S A. 104(27):11489-94 (Selected for F1000 prime :

* indicates equal contribution

# indicates corresponding author(s)