• Lee SI*, Lim HJ*, Kim NY, Cho J, Lee H, Moon DW#, Seo J#, (Submitted)
  • Lee J*, Lee H*, Lee H, Shin M, Shin M, Seo J, Lee E, Park SA, Park S. (In revision)
  • Lee H*, Cho S*, Kim MJ, Park YJ, Cho E, Jo YS, Kim YS, Woo SH, Lee YS, Suh BC, Yoon JH, Go Y#, Lee IK#, Seo J#. ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes Cell Rep (Accepted) 
  • Kim MY, Kim MJ, Lee C, Lee J, Kim SS, Kim HT, Seo J, Yoon KJ#, Han S#. Trametinib activates endogenous neurogenesis and recovers neuropathy in a model of Alzheimer’s disease. Exp Mol Med (Accepted)
  • Park JH*, Hwang JW,* Jang GM, Jeong YJ, Cho J, Seo J#, Heo HS#. Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation through NLRP3 and DYRK1A/GSK3beta. Front Immunol 14:1150940
  • Pao PC, Seo J, Lee A, Kritskiy O, Patnaik D, Penney J, Raju RM, Geigenmuller U, Silva MC, Lucente DE, Gusella JF, Dickerson BC, Loon A, Yu MX, Bula M, Yu M, Haggarty SJ, Tsai LH. A novel Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes. Proc Natl Acad Sci U S A 120(16) e2217864120


  • Jeon H, Kim YJ, Huang SK, Seo J, Mun JY (2022) Restoration of cathepsin D level via L-serine recovers PPA-induced lysosomal dysfunction in neuronal cells. Int. J. Mol. Sci  2022 23(18), 10613
  • Choi HJ, Park JH, Jeong YJ, Hwang JW, Lee S, Lee H, Seol E, Kim IK, Cha BY, Seo J, Moon M, Heo HS (2022) Donepezil ameliorates Aβ pathology but not tau pathology in 5XFAD mice. Mol. Brain. 2022 15(1), 63
  • Kim J*, Park D*, Seo NY*, Yoon TH*, Kim GH, Lee SH, Seo J, Um JW, Lee KJ#, Ko J# (2022) LRRTM3 regulates activity-dependent synchronization of synapse properties in topographically connected hippomcampal neural circuits. Proc Natl Acad Sci U S A. 119(3) e2110196119:


  • Lee D*, Seo J*, Jeong HC, Lee H#, Lee SB# (2021) The perspectives of early diagnosis of schizophrenia through the detection of epigenomics-based biomarkers in iPSC-derived neurons. Front Mol Neurosci  14:756613
  • Cho S, Lee H, Jung M, Hong K, Woo SH, Lee YS, Kim BJ, Jeon MY, Seo J#, Mun JY# (2021) Neuromyelitis optica(NMO)-IgG-driven organelle reorganization in human iPSC-derived astrocytes. FASEB J  35(10):e21894
  • Lee SI, Jeong W, Lim H, Cho S, Lee H, Jang Y, Cho J, Bae S, Lin YT, Tsai LH, Moon DW, Seo J (2021) ApoE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid rafts expansion and Aβ generation. Stem Cell Reports  16(9):2128-2137
  • Cho S, Lee H, Seo J (2021) Impact of genetic risk factors for Alzheimer’s disease on brain glucose metabolism. Mol Neurobiol  58(6):2608-2619
  • Park JC, Jang SY, Lee D, Lee J, Kang U, Chang H, Kim HJ, Han SH, Seo J, Choi M, Lee DY, Byun MS, Yi D, Cho KH, Mook-Jung I (2021) A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids. Nat Commun  12(1):280


  • Narayan P*, Sienski G*, Bonner JM, Lin YT, Seo J, Baru V, Haque A, Milo B, Akay L, Graziosi A, Freyzon Y, Landgraf D, Hesse WR, Valastyan J, Barrasa MI, Tsai LH#, Lindquist S# (2020) PICALM rescues endocytic defects caused by the Alzheimer’s disease risk factor APOE4. Cell Rep  33(1):108224
  • Park JH*, Chung CG*, Seo J, Lee BH, Lee YS, Kweon JH#, Lee SB# (2020) C9orf72-associated arginine-rich dipeptide repeat proteins reduce the number of golgi outposts and dendritic branches in Drosophila Neurons. Mol Cells  43(9):821-830
  • Han KM*, Kang RJ*, Jeon H*, Lee HJ, Lee JS, Park HH, Jeon SG, Suk K, Seo J#, Hoe HS# (2020) Regorafenib regulates AD pathology, neuroinflammation, and denderitic spinogenesis in Cells and a mouse model of AD. Cells 9(7):1655
  • Lee D*, Choi YH*, Seo J, Kim JK#, Lee SB# (2020) Discovery of new epigenomics-based biomarkers and the early diagnosis of neurodegenerative diseases. Ageing Res Rev  61:101069


  • Jeong W, Lee H, Cho S, Seo J (2019) ApoE4-induced cholesterol dysregulation and its brain cell type-specific implications in the pathogenesis of Alzheimer’s disease. Mol Cells  42(11):739-746
  • Meyer K*, Feldman HM*, Lu T, Drake D, Lim ET, Ling KH, Bishop NA, Pan Y, Seo J, Lin YT, Su SC, Church GM, Tsai LH, Yankner BA (2019) REST and neural gene network dysregulation in iPSC models of Alzheimer’s disease. Cell Rep 26(5):1112-1127


  • Jung YJ*, Kim YH*, Bhalla M, Lee SB#, Seo J# (2018) Genomics: New light on Alzheimer’s disease research. Int. J. Mol. Sci 19(12):3771
  • Lin YT*, Seo J*, Gao F, Feldman HM, Wen HL, Penney J, Cam HP, Gjoneska E, Raja WK, Cheng J, Rueda R, Kritskiy O, Abdurrob F, Peng Z, Milo B, Yu CJ, Elmsaouri S, Dey D, Ko T, Yankner BA, Tsai LH (2018) APOE4 causes widespread molecular and cellular alterations associated with Alzheimer’s disease phenotypes across human iPSC-derived brain cell types. Neuron 98(6):1141-1154.
  • Godin S, Seo J, Tsai LH. ‘Neurodegenerative diseases and the aging brain’ in The molecular and cellular basis of neurodegenerative diseases (2018) Wolfe M. ed. ELSEVIER (Book Chapter)


  • Seo J*, Kritskiy O*, Watson LA, Barker SJ, Dey D, Raja WK, Lin YT, Ko T, Cho S, Penney J, Silva MC, Sheridan SD, Lucente D, Gusella JF, Dickerson BC, Haggarty SJ, Tsai LH (2017) Inhibition of p25/Cdk5 attenuates tauopathy in mouse and iPSC models of frontotemporal dementia. J Neurosci 37(41):9917-9924.
  • Penney J, Seo J, Kritskiy O, Elmsaouri S, Gao F, Pao PC, Su SC, Tsai LH (2017) Loss of protein arginine methyltransferase 8 alters synapse composition and function, resulting in behavioral defects. J Neurosci 37(36):8655-8666.
  • Shukla V, Seo J, Binukumar BK, Amin ND, Reddy P, Grant P, Kuntz S, Kesavapany S, Steiner J, Mishra SK, Tsai LH, Pant HC. (2017) TFP5, a peptide inhibitor of aberrant and hyperactive Cdk5/p25 attenuates pathological phenotypes and restores synaptic function in CK-p25Tg mice. J Alzheimers Dis 56(1):335-349.


  • Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH. (2016) Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature 540 (7632):230-235.
  • Raja WK, Mungenast AE, Lin YT, Ko T, Abdurrob F, Seo J, Tsai LH. (2016) Self-organizing 3D human neural tissue derived from induced pluripotent stem cells recapitulate Alzheimer’s disease phenotypes. PLoS One 11(9):e0161969


  • Madabhushi R, Gao F, Pfenning AR, Pan L, Yamakawa S, Seo J, Rueda R, Phan TX, Yamakawa H, Pao PC, Stott RT, Gjoneska E, Nott A, Cho S, Kellis M, Tsai LH. (2015) Activity-induced DNA breaks govern the expression of neuronal early-response genes. Cell 161(7):1592-605.
  • Siegert S, Seo J*, Kwon EJ*, Rudenko A*, Cho S, Wang W, Flood Z, Martorell AJ, Ericsson M, Mungenast AE, Tsai LH. (2015) The schizophrenia risk gene product miR-137 alters presynaptic plasticity. Nat Neurosci 18(7):1008-16.
  • Rei D, Mason X*, Seo J*, Gräff J, Rudenko A, Wang J, Rueda R, Siegert S, Cho S, Canter RG, Mungenast AE, Deisseroth K, Tsai LH. (2015) Basolateral amygdala bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway. Proc Natl Acad Sci U S A 112(23):7291-6.
  • Rudenko A*, Seo J*, Hu J, Su SC, de Anda FC, Durak O, Ericsson M, Carlen M, Tsai LH. (2015) Loss of cyclin-dependent kinase 5 from parvalbumin interneurons leads to hyperinhibition, decreased anxiety, and memory impairment. J Neurosci 35(6):2372-83.
  • Park H*, Han KS*, Seo J*, Lee J*, Dravid SM, Woo J, Chun H, Cho S, Bae JY, An H, Koh W, Yoon BE, Berlinguer-Palmini R, Mannaioni G, Traynelis SF, Bae YC, Choi SY, Lee CJ. (2015) Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors. Mol Brain 8(1):7.
  • Nott A, Cho S, Seo J, Tsai LH. (2015) HDAC2 expression in parvalbumin interneurons regulates synaptic plasticity in the mouse visual cortex. Neuroepigenetics 1:34-40.


  • Seo J, Tsai LH. (2014) Neuronal differentiation: 5-HT6R can do it alone. Nat Chem Biol 10(7):488-9.
  • Seo J, Giusti-Rodriguez P, Zhou Y, Rudenko A, Cho S, Ota KT, Park C, Patzke H, Madbhushi R, Pan L, Mungenast AE, Guan JS, Delalle I, Tsai LH. (2014) Activity-dependent p25 generation regulates synaptic plasticity and Aβ-induced cognitive impairment. Cell 157(2):486-98.
  • Gräff J, Joseph NF, Horn ME, Samiei A, Meng J, Seo J, Rei D, Bero AW, Phan TX, Wagner F, Holson E, Xu J, Sun J, Neve RL, Mach RH, Haggarty SJ, Tsai LH. (2014) Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories. Cell 156(1-2):261-76.


  • Rudenko A, Dawlaty MM, Seo J, Cheng AW, Meng J, Le T, Faull KF, Jaenisch R, Tsai LH. (2013) Tet1 is critical for neuronal activity-regulated gene expression and memory extinction. Neuron 79(6);1109-22.


  • Seo J*, Hong J*, Lee SJ, Choi SY. (2012) c-Jun N-terminal phosphorylation is essential for hippocampal synaptic plasticity. Neurosci Lett 531(1):14-9.
  • Su SC, Seo J, Pan JQ, Samuels BA, Rudenko A, Ericsson M, Neve RL, Yue DT, Tsai LH. (2012) Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5. Neuron 75(4):675-87.
  • Kang JA, Lee K, Lee KM, Cho S, Seo J, Hur EM, Park CS, Baik JH, Choi SY. (2012) Desipramine inhibits histamine H1 receptor-induced Ca2+ signaling in rat hypothalamic cells. PLoS One 7(4):e36185
  • Gräff J, Rei D, Guan JS, Wang WY, Seo J, Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M, Su SC, Samiei A, Joseph N, Haggarty SJ, Delalle I, Tsai LH. (2012) An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature 483(7388):222-6.
  • Seo J, Kim K, Jang S, Han S, Choi SY, Kim E. (2012) Regulation of hippocampal LTP and LTD by diacylglycerol kinase zeta. Hippocampus 22(5):1018-26.


  • Won H, Mah W, Kim E, Kim JW, Hahm EK, Kim MH, Cho S, Kim J, Jang H, Cho SC, Kim BN, Shin MS, Seo J, Jeong J, Choi SY, Kim D, Kang C, Kim E. (2011) GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice. Nat Med 17(5):566-72.
  • Yang J*, Seo J*, Nair R, Han S, Jang S, Kim K, Han K, Paik SK, Choi J, Lee S, Bae YC, Topham MK, Prescott SM, Rhee JS, Choi SY, Kim E. (2011) DGKi regulates presynaptic release, excitatory transmission, and presynaptic mGluR-LTD. EMBO J 30(1): 165-80.


  • Hong J, Cho IH, Suh EC, Kwak KI, Seo J, Choi SY Park HW, Jo EK, Lee S, Lee K, Lee SJ. (2010) Microglial Toll-like receptor 2 contributes to kainic acid-induced glial activation and hippocampal neuronal cell death. J Biol Chem 285(50): 39447-57.
  • Oh D*, Han S*, Seo J*, Lee JR*, Cho J, Groffen J, Kim K, Cho YS, Choi HS, Shin H, Woo J, Won H, Park SK, Kim SY, Jo J, Whitcomb DJ, Cho K, Kim H, Bae YC, Heisterkamp N, Choi SY, Kim E. (2010) Regulation of Synaptic Rac1 Activity, LTP maintenance, and Learning and Memory by BCR and ABR Rac GTPase- activating proteins. J Neurosci 30(42): 14134-44.
  • Seo J*, Koo NY*, Choi W Y, Kang JA, Min JH, Jo SH, Lee SJ, Oh SB, Kim JS, Lee JH, Choi SY, Park K. (2010) Sphingosine-1-phosphate Signaling in Human Submandibular Cells. J Dent Res. 89(10): 1148-53.


  • Han K*, Kim MH*, Seeburg D, Seo J, Verpelli C, Han S, Chung HS, Ko J, Lee HW, Kim K, Heo WD, Meyer T, Kim H, Sala C, Choi SY, Sheng M, Kim E. (2009) Regulated RalBP1 binding to RalA and PSD-95 controls AMPA receptor endocytosis and LTD. PLoS Biol. 7(9):e1000187.
  • Kim K, Yang J, Zhong XP, Kim MH, Kim YS, Lee HW, Han S, Choi J, Han K, Seo J, Prescott SM, Topham MK, Bae YC, Koretzky G, Choi SY, Kim E. (2009) Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance. EMBO J. 28(8):1170-9.
  • Kim MH*, Choi J*, Yang J*, Chung W*, Kim JH, Paik SK, Kim K, Han S, Won H, Bae YS, Cho SH, Seo J, Bae YC, Choi SY, Kim E. (2009) Enhanced NMDA receptor-mediated synaptic transmission, enhanced long-term potentiation, and impaired learning and memory in mice lacking IRSp53. J Neurosci. 29(5):1586-95.


  • Hayashi ML, Rao BS, Seo J, Choi HS, Dolan BM, Choi SY, Chattarji S, Tonegawa S. (2007) Inhibition of p21- activated kinase rescues symptoms of fragile X syndrome in mice. Proc Natl Acad Sci U S A. 104(27):11489-94

* indicates equal contribution

# indicates corresponding author(s)